PREP 2024

36th International Symposium on Preparative and Process Chromatography

 Philadelphia, PA, United States    May 28-31, 2024

Plenary Speakers

Molecular Bioprocessing: Biophysics, Simulations and Expedited Process Development (PL 1)

Prof. Steven CRAMER M
RENSSELAER POLYTECHNIC INSTITUTE, Troy, United States
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Enabling Sustainability in Chromatography via Innovation (PL 2)

Dr David ROUSH
ROUSH BIOPHARMA PANACEA , Colts Neck, United States
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Oral Communications

Counter-current Chromatography for Efficient Lignin Monomer-monomer and Monomer-oligomer Separations from Lignin Oil Derived from Reductive Catalytic Fractionation

Dr Manar ALHERECH
NATIONAL RENEWABLE ENERGY LABORATORY, Golden, United States
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Elucidating the Exclusion Mechanism in Cation-exchange Chromatography with High-throughput Techniques and Mechanistic Modeling to Improve Performance of Therapeutic Antibody Polishing

Dr Scott ALTERN
ABBVIE, Worcester, United States
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Session Chair

Prof. Dorota ANTOS
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland

Advancing Rapeseed Protein Purification: A Continuous Chromatographic Approach for Napin and Cruciferin

Mr Jonas ARNECKE
UNIVERSITY OF APPLIED SCIENCES MANNHEIM, Mannheim, Germany
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All-atom Modelling of Methacrylate-based Multi-modal Chromatography Resins for Isotherm Parameter Prediction

Mr Tim BALLWEG
KARLSRUHER INSTITUTE OF TECHNOLOGY, Karlsruhe, Germany
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Optimization For the Separation of Oligosaccharides by SMB

Ms Xiaoqing BAO
JOPE TECHNOLOGY CO., LTD , Kaohsiung, Taiwan
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Optimizing Plasmid DNA Purification: Anion Exchange Membrane Chromatography with Salt Modulation

Ms Pauline BEWOSCH
HS MANNHEIM , Mannheim, Germany
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Mechanistic Modeling of mAbs And Host-cell Protein Impurities in Protein a Chromatography

Mr Soumitra BHOYAR
UNIVERSITY OF DELAWARE, Newark, United States
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Antibody Capture from Non-clarified Cell Broth Based on Superparamagnetic Protein a Functionalized Beads

Dr Nils BRECHMANN
MAGIC BIOPROCESSING, Uppsala, Sweden

Process Analytical Technology (PAT) Informing the Manufacture and Formulation of Monoclonal Antibody-based Products

Ms Maria BRUQUE
UNIVERSITY OF BIRMINGHAM, Birmingham, United Kingdom

Prediction Precision of Hydrophobic Interaction Chromatography Can Be Improved with a Flexible Isotherm

Prof. Johannes BUYEL
BOKU, Vienna, Austria
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Evaluation of Large-scale Monolith Chromatographic Columns for AAV Capsids Separation

Dr Urh CERNIGOJ
SARTORIUS BIA SEPARATIONS, Ajdovscina, Slovenia
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Adapting High-throughput Technologies for Enhanced Mechanistic Modeling in Chromatography: A Novel Calibration Approach Combining KP And Robocolumn

Dr Chyi-Shin CHEN
CHUGAI PHARMACEUTICAL, Tokyo, Japan
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New Monodispersed Silica and Hybrid Silica Bulk Media for Purification of Peptides and Oligonucleotides

Dr WU CHEN
NANOMICRO TECHNOLOGY, NEWARK, United States
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Implementation of 3D Printed Integrated Clarification and Capture Columns for Antibody Purifications

Ms Mariachiara CONTI
THE UNIVERSITY OF EDINBURGH, Edinburgh, United Kingdom

Adapting the Separation Parameters to Address an Unexpected Impurity in a Validated Process

Dr Olivier DAPREMONT
SK PHARMTECO, Rancho Cordova, United States
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Innovations in Enhanced SFC: Complex Purification Enabled by Recent Advances in Analytical and Preparative Enhanced Fluid Chromatography

Mr Jimmy DASILVA
MERCK & CO., INC., Rahway, United States

Green Purification of CROCIN-I from Saffron Through the Combination of Multicolumn Countercurrent Chromatography and Ethanol

Dr Chiara DE LUCA
UNIVERSITÀ DEGLI STUDI DI FERRARA, Ferrara, Italy
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High Throughput Evaluation of Membrane Chromatographic Selectivities

Mr Eric DENBAUM
RENSSELAER POLYTECHNIC INSTITUTE, Troy, United States
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Developing Continuous Multi-column Chromatography Platforms for Virus-like Particles (VLP): A Transition from Batch to Continuous Vaccine Production

Dr Kabir DHINGRA
MERCK, West Point, United States
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Large Scale Purification of Peptides with MCSGP Under GMP

Dr Ralf EISENHUTH
BACHEM AG, Bubendorf, Switzerland

Going Deep: Understanding Electrostatic Interaction on Strong Cation-Exchanger Via CO-ION Valency Effects

Mr Gregor ESSERT
TECHNISCHE UNIVERSITÄT MÜNCHEN, Garching, Germany
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Improved Manufacturing and Characterization of a Fusogenic Oncolytic Virus

Ms Rita FERNANDES
IBET, Oeiras, Portugal

A Machine Learning Methodology for Resin Screening in Protein a Chromatography

Ing Andrea GALEAZZI
IMPERIAL COLLEGE LONDON, London, United Kingdom
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Displacement Effects on the Purification of GLP-1 Receptor Agonists

Dr André GARCIA
KROMASIL BY NOURYON, Bohus, Sweden

Impact of Jetting and Batch Emulsification Resin Manufacturing Technologies on Pressure-flow Characteristics

Mr Christopher GERBERICH
GSK, King of Prussia, United States
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Size-exclusion Chromatography Sensor as a Process Analytical Technology for the Manufacturing Process of Monoclonal Antibodies

Dr Fabrice GRITTI
WATERS CORPORATION, MILFORD, United States
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Solutions for Reduced Carbon Footprint and Direct Freshwater Use in MAB Manufacturing

Mrs Anna GRONBERG
CYTIVA, UPPSALA, Sweden
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Development of a Custom, High Throughput Purification Platform in Support of Peptide Purification

Ms Cristina GROSANU
J&J, Spring House, United States
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A Flexible Approach to Automated High-throughput Purification to Enable Drug Discovery

Ms Amber GUILLEN
NURIX, San Francisco, United States

Predictability of Two-Component Protein Column Adsorption with Isotherm Models using Batch Experiments

Prof. Rainer HAHN
BOKU VIENNA, Vienna, Austria
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Scale-Bridging Separation of Gold Nanoclusters and Plasmonic Nanoparticles by Liquid Chromatography

Mr Lukas HARTMANN
FRIEDRICH-ALEXANDER-UNIVERSITY ERLANGEN-NUREMBERG, Erlangen, Germany

Optimizing Bioprocess Efficiency: A Toolbox Approach to Downstream Intensification and Facility Integration

Dr Matthias HECHT
BOEHRINGER INGELHEIM, Biberach, Germany

Introducing Green Flash Chromatography

Dr Kenneth JAMES
G-FLASH LLC, Newark, United States
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High Resolution 3D Imaging to Visualize and Characterize 3D Printed Chromatography Columns

Dr Thomas JOHNSON
UNIVERSITY COLLEGE LONDON, London, United Kingdom

Integrated Model-based Design and Scale-up for a Peptide Chromatographic Purification Process

Dr Bhoja KANDELA
ELI LILLY SERVICES INDIA PRIVATE LIMITED, Bangalore, India
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Separation and Analysis of Adeno-associated Virus Vectors Using Choline Gradient Salts in Anion-exchange Chromatography

Dr Jukka KERVINEN
TOSOH BIOSCIENCE LLC, King of Prussia , United States
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Employing Arginine and Trehalose for Improved Recovery in a Two Stage Lentiviral Vector Purification Process

Mr Andrew KOCOT
RENSSELAER POLYTECHNIC INSTITUTE, Troy, United States
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Development of a Convective Flow-based Chromatography Step for the Enrichment of Full Adeno-associated Viral Vectors

Ms Susanne KONRAD
ROCHE DIAGNOSTICS GMBH, Penzberg, Germany
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In-line Tools for SMB Method Development in Lab Scale Used for Purification of Natural Compounds

Dr Yannick KRAUKE
KNAUER, Berlin, Germany

Development of Rabbit scFv-based Immunoaffinity Chromatography for Purification of Human Kynureninase

Prof. Yoichi KUMADA
KYOTO INSTITUTE OF TECHNOLOGY, Kyoto, Japan

Investigation of Retrovirus Like Particle Clearance Across Operational Ranges for Hydrophobic Interaction Chromatography Steps Using MOCKV® RVLPS

Ms Marisa LABANCA
BIOGEN, INC., Morrisville, United States
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Characterization of Novel High-performance Chromatography Membranes and Devices for Product Capture

Dr Joseph LAVOIE
NC STATE UNIVERSITY, Cary, United States
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Continuous Ternary Separation Using Double-layer Simulated Moving Bed Chromatography

Dr Ju Weon LEE
MAX-PLANCK-INSTITUT FUR DYNAMIK KOMPLEXER TECHNISCHER SYSTEME, Magdeburg, Germany

Case Studies: Downstream Process Development and Platform Evolution for Fragmented-antibody-based Protein Therapeutics for Inhalation Delivery

Dr Haibin LUO
ASTRAZENECA, Gaithersburg, United States

Ionic Strength Effects in Protein a Affinity Membrane Chromatography

Mr Oussama MENOUAR MENARI GHEZIEL
STEINBEIS-TRANSFERZENTRUM A. D. HOCHSCHULE MANNHEIM, Mannheim, Germany
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Hybrid Models and Knowledge Transfer for Biopharmaceutical Processes

Prof. Massimo MORBIDELLI
POLITECNICO DI MILANO, Milano, Italy
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Automated System for Modelling, Calibration and Optimization of Chromatographic Separations of Biologics

Prof. Bernt NILSSON
LUND UNIVERSITY, Lund, Sweden

Effect of Microstructure and Porosity on Compression of Methacrylate Polymers During Flow-through Applications

Dr Ales PODGORNIK
FACULTY OF CHEMISTRY AND CHEMICAL TECHNOLOGY, UNIVERSITY OF LJUBLJANA, Ljubljana, Slovenia

Twin-column Chromatography for Isolating mAb Isoforms and Other Pharmaceutical Minor Components

Dr J. PRESTON
YMC, Devens, United States
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Spatial Discontinuous Galerkin Spectral Element Method for a Family of Chromatography Models in Cadet

Mr Johannes SCHMÖLDER
FORSCHUNGSZENTRUM JÜLICH GMBH, Jülich, Germany

Lab Scale Chiral Chromatography: Evolution and Application to Lilly Early Drug Discovery Efforts

Mr Eric SEEST
ELI LILLY, Indianapolis, United States
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Influence of CHO Clonal Variations on Polysorbate 20 Degradation Kinetics in Monoclonal Antibody Formulations

Dr Tanja SEIBOLD
BOEHRINGER INGELHEIM, Biberach, Germany

Process Intensification of rAAV Using Column-free Continuous Countercurrent Tangential Chromatography (CCTC)

Dr Oleg SHINKAZH
CHROMATAN, Dedham, United States
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Towards Development of Peptide-based Host Cell Protein Removal Technologies for Biomanufacturing

Ms Sobhana Alekhya SRIPADA
NORTH CAROLINA STATE UNIVERSITY, Raleigh, United States

Innovative Mixed Mode Resin for Efficient Purification of Complex Antibody Formats: Impurity Removal and High Purity Bispecific Antibody Recovery

Mrs Alisa STROBEL
MILLIPORESIGMA, Darmstadt, Germany
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The New Frontier? Exploring Innovative Magnetic Separation with Mechanistic Models

Mr Marko TESANOVIC
TU MUNICH, München, Germany
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A Platform Strategy for the Development of Polishing Chromatography Steps

Dr Steve TIMMICK
GSK, Plymouth Meeting, United States
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On the Challenges of Reactive Chromatography: Estimation of Kinetics and Thermodynamics of Lactose Mutarotation

Mr Silvio TRESPI
ETH ZÜRICH, Zürich, Switzerland
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ION Exchange as a Sustainable Alternative to Reversed Phase Chromatography for the Purification of Tides Molecules

Dr Cecilia UNOSON
BIO-WORKS, Uppsala, Sweden
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Improved Process Development and Robust Scale-Down Models for Live Virus and Virus Like Particle Purification using Automated High Throughput Chromatography Platform

Ms Sheng-Ching WANG
MERCK, West Point, United States

Continuous Separation of Enantiomers in SMB Chromatography with Achiral Stationary Phase

Dr Marek WOJCIECH
RZESZOW UNIVERSITY OF TECHNOLOGY, Rzeszow, Poland
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Purification of Therapeutic Proteins Expressed in Mammalian Hosts Using a Self-removing Affinity Tag

Prof. David WOOD
THE OHIO STATE UNIVERSITY, Columbus, United States

Efficient Capture of Adenovirus Serotype 5 from Multi-cell Culture Fluids by Affinity Ligands Targeting Hexon Protein

Mr Yuxuan WU
NORTH CAROLINA STATE UNIVERSITY, Raleigh, United States
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A Method for Determining the Optimum Temperature for a Polyphenol Separation Process by Polymer-resin Based Reversed Phase Chromatography

Prof. Shuichi YAMAMOTO
YAMAGUCHI UNIVERSITY, Ube, Japan

Reversed-phase Microscale Isolations of Various Modalities

Ms Crystal YE
GENENTECH, South San Francisco, United States
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Converting Aggregates to Monomers by Reducing Agents for an ADC, and by Low PH Treatment for a MAB

Dr Geng YU
SALUBRIS BIOTHERAPEUTICS, GAITHERSBURG, United States